| Date | Opponent | Location | Time | Media | Score | |
|---|---|---|---|---|---|---|
| 09/01/16 | vs. Appalachian State | Knoxville, TN | 3:00pm CST | ESPN | W, 20-13 (OT) | More |
| 09/10/16 | vs. Virginia Tech | Bristol, TN | 7:00pm CST | ABC | W, 45-24 | More |
| 09/17/16 | vs. Ohio | Knoxville, TN | 11:00am CST | ESPN | W, 28-19 | More |
| 09/24/16 | vs. Florida* | Knoxville,TN | 3:30pm E.T. | CBS | W, 38-28 | More |
| 10/01/16 | at Georgia* | Athens,GA | W, 34-31 | More | ||
| 10/08/16 | at Texas A&M* | College Station, TX | L, 45-38 OT | More | ||
| 10/15/16 | vs. Alabama* | Knoxville,TN | L, 49-10 | More | ||
| 10/29/16 | at South Carolina* | Columbia, SC | L, 24-21 | More | ||
| 11/05/16 | vs Tennessee Tech | Knoxville, TN | W, 55-0 | More | ||
| 11/12/16 | vs. Kentucky* | Knoxville, TN | W, 49-36 | More | ||
| 11/19/16 | vs. Missouri* | Knoxville, TN | W, 63-37 | More | ||
| 11/26/16 | at. Vanderbilt* | Nashville, TN | L, 45-34 | More | ||
| 12/30/16 | vs. Nebraska | Nashville, TN | 2:30pm CST | ESPN | W,38-24 | More |
Schedule